Scientific Publications


Spugnini EP, Melillo A, Quagliuolo L, Boccellino M, Vincenzi B, Pasquali P, Baldi A.

Definition of novelelectrochemotherapy parameters and validation of their in
vitro and in vivo effectiveness.

J Cell Physiol. 2014 Sep;229(9):1177-81. Doi: 10.1002/jcp.24548. PubMed PMID:24403005,


Spugnini EP, Baldi A

Electrochemotherapy in veterinary oncology: from rescue to first line therapy.

Methods Mol Biol. 2014;1121:247-56.doi:10.1007/978-1-4614-9632-8_22. Review. PubMed PMID: 24510829


Lanza A, Baldi A, Spugnini EP

Surgery and electrochemotherapy for the treatment of cutaneous squamous cell carcinoma in a yellow-bellied slider (Trachemysscripta scripta).

J Am Vet Med Assoc. 2015 Feb 15;246(4):455-7. Doi:10.2460/javma.246.4.455. PubMed PMID:25632821,


Spugnini EP,M Pizzuto,M Filipponi,L Romani, B Vincenzi,F Menicagli

Electroporation Enhances Bleomycin Efficacy in Cats with Periocular Carcinoma and Advanced Squamous Cell Carcinoma ofthe Head – Journal of Veterinary Internal Medicine(Impact Factor: 1.88),


Spugnini, E.P., Bolaffio, C., Scacco, I. and Baldi, A

Electrochemotherapy increases local control after incomplete excision of a recurring penile fibrosarcoma in a stallion.

Open Vet. J. 6(3), 234-237,


Lanza A, Pettorali M, Baldi A, Spugnini EP

Surgery and electrochemotherapy treatment of incompletely excised mammary carcinoma in two male pet rats (Rattus norvegicus).

J. Vet. Med. Sci. In press (2017),



Spugnini EP, Menicagli F, Pettorali M, Baldi A.

Ultrasound guided electrochemotherapy for the treatment of a clear cell thymoma in a cat.

Open Vet j. 2017;7(1):57-60. Doi: 10.4314/ovj.v7i1.8. Epub 2017 Mar 8. PubMed PMID: 28331834; PubMed Central PMCID: PMC5356291,


Spugnini EP, Bolaffio C, Scacco L, Baldi A.

Isolated limb perfusion electrochemotherapy for the treatment of an advanced squamous cell carcinoma of the hoof in a mare.

Open Vet J. 2017;7(2):192-196. Doi: 10.4314/ovj.v7i2.18. Epub 2017 Jun 28. PubMed PMID: 28717603; PubMed Central PMCID: PMC5498771,


Pasquali P, Freites-Martinez A, Gonzalez S, Spugnini EP, Baldi A

Successful treatment of plantar warts with intralesional bleomycin and electroporation: pilot prospective study.

Dermatol Pract Concept. 2017 Jul 31;7(3):21-26. Doi: 10.5826/dpc.0703a04. eCollection 2017 Jul. PubMed PMID: 29085716; PubMed Central PMCID: PMC5661162,


Pasquali P, Spugnini EP, Baldi A.

Successful Treatment of a Keratoacanthoma with Electrochemotherapy: A Case Report.

Dermatol Ther (Heidelb). 2018
Mar;8(1):143-146. Doi: 10.1007/s13555-018-0222-9. Epub 2018 Jan 24. PubMed PMID: 29368221; PubMed Central PMCID: PMC5825327,


Spugnini EP, Lanza A., Sebasti S., Baldi A.

Electrochemotherapy palliation of an oral squamous cell carcinoma in an African hedgehog (Atelerix albiventris),

Epub Autumn 2018, Veterinary Research Forum. 2018; 9 (4) 379 – 381 doi: 10.30466/vrf.2018.33109,


Enrico P. Spugnini, Bruno Vincenzi, Bruno Amadio, Alfonso Baldi,

Adjuvant electrochemotherapy with bleomycin and cisplatin combination for canine soft tissue sarcomas: A study of 30 cases,

Open Veterinary Journal, (2019), Vol. 9(1): 88–93, Published: 25/03/2019,


 Spugnini EP, Baldi A,

Electrochemotherapy in Veterinary Oncology: State-of-the-Art and Perspectives,

Vet Clin North Am Small Anim Pract. 2019 Sep; 49(5):967-
979. Doi: 10.1016/j.cvsm.2019.04.006. Epub 2019 Jun 6,


Carafa V, Nebbioso A, Cuomo F, Rotili D, Cobellis G, Bontempo P, Baldi A, Spugnini EP, Citro G, Chambery A, Russo R, Ruvo M, Ciana P, Maravigna L, Shaik J, Radaelli E, De Antonellis P, Tarantino D, Pirolli A, Ragno R, Zollo M, Stunnenberg HG, Mai A, Altucci L.

RIP1-HAT1-SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer.

Clin Cancer Res. 2018 Jun 15;24(12):2886-2900


Lanza A., Baldi A., Rossi G., Spugnini EP.,

Electrochemotherapy for the treatment of an incompletely excised subcutaneous low-grade epithelioid hemangioendothelioma in a budgerigar parakeet (Melopsittacus 2ndulates),

Open Veterinary Journal, (2019), Vol.9(3): 269–272, DOI:


Dos Anjos D. S. and others,

Outcome Following Curative-Intent Electrochemotherapy for Extramedullary Plasmocytoma in Dogs – Case Reports,


Dos Anjos D. S. and others,

Response dataset from canine extramedullary plasmacytoma treated with lipophobic drugs enhanced by electroporation,


Spugnini EP, Dos Anjos DS and others,

Preliminary assessment of electrochemotherapy feasibility in dogswith vesical transitional cell carcinoma,


Spugnini EP, A.Baldi, et others,

Definition of a Novel Plasmid-Based Gene Transfection Protocol of Mammalian Skeletal Muscles by Means of In Vivo Electroporation, September 2020,


Denner S. Dos Anjos, Oscar R. Sierra, Enrico P. Spugnini, Andrigo B. De Nardi & Carlos E. Fonseca-Alves,

Comparison of two different doses of bleomycin in electrochemotherapy protocols for feline cutaneous squamous cell carcinoma nonsegregated from ultraviolet light exposure,


Valenti P., Menicagli F., Baldi A., Barella G., Catalucci C., Attorri V., Spugnini EP.,

Evaluation of electrochemotherapy in the management of apocrine gland ana sac adenocarcinomas in dogs: A retrospective study,


Enrico P. Spugnini, Licia Scacco, Carlo Bolaffio, Alfonso Baldi,

Electrochemotherapy for the treatment of cutaneous solid tumors in equids: A retrospective study.


Ygor Amaral Rossi , Leticia Ribeiro, Regina Mendes Medeiros , Enrico Spugnini , Carlos Eduardo Fonseca Alves & Denner Santos Dos Anjos,

Primary Perianal Malignant Melanoma in a Dog – Combination Therapy,


Spugnini EP, Menditti D, De Luca A, Baldi A.

Electrochemotherapy in Translational Medicine: From veterinary Experience to Human Oncology.


Condello M, D’Avack G, Spugnini EP, Meschini S.

Electrochemotherapy: An Alternative Strategy for Improving Therapy in Drug-Resistant SOLID Tumors.

Cancers (Basel). 2022