Successful treatment of plantar warts with intralesional bleomycin and electroporation: pilot prospective study.
Our electroporators allow us to treat benign skin tumors and local neoplasms also in humans. In this regard, the Biopulse Biotech research group, have carried out several studies and scientific collaborations. For example, the pilot prospective study on the successful treatment of plantar warts with intralesional bleomycin and electroporation. The study was completed with the Department of Dermatology of the Pius Hospital de Valls, Spain. Scientific director of the project was Dr. Paola Pasquali, doctor and scientist specializing in applications of physical therapy in dermatology. The study’s cohort included 12 men and 10 women, with a mean age of 53.8 years. A total of 22 warts were treated. In dividing the patients in two groups (complete remission against all the others) and analyzing the different outcomes in the two arms of patients, a statistical significant difference was found (p=0.0015), proving a greater efficacy of the treatment with bleomycin combined with ECT as opposed to bleomycin alone. Electroporation was always well tolerated by the patients with no discomfort. This study serves as a basis for the application of novel protocols in the treatment of different benign and locally malignant skin lesion by means of electroporation. The study was registered in the Spanish Ministry of Health with the number 2014-003339-21.
Pasquali P, Freites-Martinez A, Gonzalez S, Spugnini EP, Baldi A. Successful treatment of plantar warts with intralesional bleomycin and electroporation: pilot prospective study. Dermatol Pract Concept. 2017 Jul 31;7(3):21-26. Doi: 10.5826/dpc.0703a04. eCollection 2017 Jul. PubMed PMID: 29085716; PubMed Central PMCID: PMC5661162 , https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661162/
Successful Treatment of a Keratoacanthoma with Electrochemotherapy: A Case Report. Dermatol Ther (Heidelb).
As part of the same pilot projects, our research group has also treated a Keratoacanthoma in an 86-year-old patient. The Keratoacanthoma was treated with intralesional bleomycin combined with electroporation. Treatment consisted of local application of shorty and intense electric pulses with Electroporator, followed by local injection of bleomycin. Electroporation was always well tolerated by the patient, with no significant complaints, and the tumor had completely regressed by day 71 of the follow-up. The results suggest that intralesional bleomycin injection combined with electroporation could represent a valid alternative therapeutic approach for the treatment of keratoacanthomas.
Pasquali P, Spugnini EP, Baldi A. Successful Treatment of a Keratoacanthoma with Electrochemotherapy: A Case Report. Dermatol Ther (Heidelb). 2018 Mar;8(1):143-146. Doi: 10.1007/s13555-018-0222-9. Epub 2018 Jan 24. PubMed PMID: 29368221; PubMed Central PMCID: PMC5825327, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825327/