Cancer in Companion Animals, an Issue of Veterinary Clinics of North America: Small Animal Practice, eBook
This issue of Veterinary Clinics: Small Animal Practice, edited by Dr. Philip Bergman and Dr. Craig Clifford, focuses on Cancer in Companion Animals. Topics include: Novel Non-Invasive Diagnostics; MCT: Cytologic and Histologic Grading Update; Sentinel LN & Sx Oncology Update; RT Oncology Update; Novel Prescriptions for LSA; Targeted Prescriptions Update; Electrochemotherapy*; Tumor Ablation; Anorexia and the Cancer Patient; Histiocytic Sarcome and HSA; Cancer Immunotherapies; and Personalized Cancer Medicine.
*Spugnini EP, Baldi A, Electrochemotherapy in Veterinary Oncology: State-of-the-Art and Perspectives
Tumor microenvironment represents a key obstacle for the effectiveness of anticancer drugs. Electrochemotherapy involves the systemic or local delivery of lipophobic drugs such as bleomycin and cisplatin, with the application of permeabilizing electric pulses having appropriate amplitude and waveforms. This greatly enhances the uptake of these drugs by an estimated factor of 700-fold for bleomycin and 4 to 8 times for cisplatin.
Because of its efficacy and limited morbidity, this therapeutic option is becoming more and more available in veterinary oncology either as an adjuvant to surgery or as first line of treatment with palliative or curative purposes.