A new scientific paper: Electrochemotherapy in a budgerigar parakeet

by Nov 22, 2018Electrochemotherapy

FROM Open Veterinary Journal, (2019), Vol. 9(3): 269–272 new publication with OnkoDisruptor ®

In this paragraph, we present a case report of a 10-year-old male budgerigar parakeet treated with combination of surgery and electrochemotherapy by our research group:

Electrochemotherapy for the treatment of an incompletely excised subcutaneous low-grade epithelioid hemangioendothelioma in a budgerigar parakeet (Melopsittacus undulatus) 

Autors: Andrea Lanza, Alfonso Baldi, Giacomo Rossi and Enrico Pierluigi Spugnini
Centro Veterinario Gianicolense, Rome, Italy
Department of Environmental, Biological and Pharmaceutical Sciences and Technologies Campania University”Luigi Vanvitelli”, Caserta, Italy
School of Biosciences & Veterinary Medicine, Matelica (MC), University of Camerino, Camerino,Italy, Biopulse srl, Naples, Italy

The chemotherapy protocols in exotic pets are still in a very early stage of development and ECT is becoming an appealing and recognized therapeutic adjuvant treatment.

Abstract. Background:

Cutaneous tumors are rarely described in avian and are frequently of viral origin. In addition, solid tumors of vascular origin are seldom reported and usually result in difficult management by surgery alone. We describe the outcome of a subcutaneous low-grade epithelioid hemangioendothelioma (EHE) treated with the combination of surgery and electrochemotherapy.

Case Description:

A 10-year-old male budgerigar parakeet (Melopsittacus undulatus) was referred for evaluation ofa 2-month non-healing exophytic mass on the left wing. The bird was bright, alert, and responsive, with a 2 × 1 cmproliferative lesion on the wing. In addition, signs of discomfort were elicited by the clinical manipulation of the wing; no otherabnormalities were detected during physical evaluation. Following hematological and imaging analysis, the parakeetwas anesthetized and the mass was surgically removed.

After that, the histopathology report came back with a diagnosis ofincompletely excised subcutaneous low-grade EHE. A surgical revision was not feasible due to the anatomical locationand tumor extension. Therefore, adjuvant electrochemotherapy was chosen to increase the chance of tumor control. Two sessions of electrochemotherapy were performed with a 2-week interval between treatments using intralesional bleomycinfollowed by trains of permeabilizing electric pulses. Side effects were not observed and the parakeet was disease-freefor 12 months when he died of acute renal failure.


In conclusion, in lieu of the incomplete surgical excision of the tumor, electrochemotherapy resulted in good local control and cosmetic appearance and should be added to the standard oncological therapies for avian.

Read the whole pdf article:


Lanza A., Baldi A., Rossi G., Spugnini EP., Electrochemotherapy for the treatment of an incompletely excised subcutaneous low-grade epithelioid hemangioendothelioma in a budgerigar parakeet (Melopsittacus undulatus), September 2019, Open Veterinary Journal, (2019), Vol. 9(3): 269–272, DOI: http://dx.doi.org/10.4314/ovj.v9i3.13